000			02937cab a22005417i 4500
001			7381857
003			OSt
005			20250628165017.0
006			m d |
007			cr| nn||||||||
008			s2015 xxk|||||s|||||||||||eng d
035			_a(Uk)013331807
035			_a(IssueARKID)ark:/81055/vdc_100025029023.0x0001cb
035			_a(oaiARKID)oai:ark:/81055/vdc_100025029148.0x000001
035			_aark:/81055/vdc_100025029061.0x000064
040			_dStEdNL _c0
100			_4Porter, Eleanor H.
245	0		_aPolly-Anna _cPorter, Eleanor H
260			_aBoston _bGrosset & Dunlap, _c1913
300			_a310p _bill. _c19.5 cm
500			_aIn: Advanced synthesis & catalysis, Vol. 357, no. 6 ( 2015), p.1245-1257.
506			_aOwing to Legal Deposit regulations this resource may only be accessed from within National Library of Scotland. For more information contact enquiries@nls.uk _5StEdNL
520			_a Abstract Utilizing ‘off the shelf’ commercially available, cheap, small synthetic molecules that mimic the efficient mediation of important bioreactions utilized by Nature is not only highly sought after but also currently highly topical. This paper details our preliminary efforts at developing a unique base‐ and metal‐free phase‐transfer‐mediated malonic acid thioester (MAHT) ‘activation protocol’ that efficiently generates (*)‐(Sb‐(Bthioesters. Our bioinspired aldol process is exceptionally mild, conducted under near neutral pH reaction conditions, does not require an inert, oxygen‐free atmosphere or anhydrous reaction conditions and is highly atom‐economic. Exemplifying the utility of our protocol, the synthesis of an array of structurally and functionally diverse (*)‐(Sb‐(Bhydroxy thioesters equipped with highly prized functionality, i.e., chlorine, bromine, fluorine, nitrile and nitro groups, is reported, as is the diastereoselective potential of this important reaction.
590			_aThis catalogue record is generated as a result of Non Print Legal Deposit processing
650		4	_aCatalysis.
650		4	_aOrganic compounds.
650		4	_aSynthesis.
650		4	_aChemistry.
650		4	_aChemistry, Technical.
650		4	_aChemistry.
650		4	_aCatalysis.
650		4	_aTechnology, Pharmaceutical.
700	1		_aBew, Sean P.
700	1		_aStephenson, G. Richard.
700	1		_aRouden, Jacques.
700	1		_aAshford, Polly‐Anna.
700	1		_aBourane, Manuel.
700	1		_aCharvet, Agathe.
700	1		_aDalstein, Virginie M. D.
700	1		_aJauseau, Raphael.
700	1		_aHiatt‐Gipson, G. D.
700	1		_aMartinez‐Lozano, Luis A.
773	0		_tAdvanced synthesis & catalysis _x1615-4169
773	0		_w(IssueARKID)ark:/81055/vdc_100025029023.0x0001cb
856	4	0	_uhttps://nls.ldls.org.uk/welcome.html?ark:/81055/vdc_100025029061.0x000064 _zView item
942			_2fc _cFIC
999			_c7716 _d7716